Multicenter Evaluation of Diagnostic Circulating Biomarkers to Detect Sight-Threatening Diabetic Retinopathy

A multicenter cross-sectional study was conducted from October 22, 2018, to December 31, 2021, to evaluate previously verified circulating biomarkers for sight threatening diabetic retinopathy (STDR) in adults 40 years and older with type 2 diabetes. The study was conducted in parallel in the UK and India. In the UK, the study population was recruited at 3 outpatient ophthalmology clinics, with 2 in London, UK, and 1 in Norwich, UK. Participant race and ethnicity information was gathered based on self-reported data and classified according to their relevant office for national statistic classification. Race and ethnicity categories included South Asian, other Asian (ie, as categorized by the UK 2011 Census, an individual who is not Bangladeshi, Chinese, Indian, or Pakistani is classified as other Asian), Black, White, and other (ie, any individual ethnicity that is not named in the UK 2011 Census). Prior studies have shown that racial and ethnic minoritized groups are disproportionately affected by STDR.5 In India, study participants were recruited at 2 centers and included exclusively people of Indian origin residing in both urban and rural regions in Tamil Nadu, India. Participant sex was determined based on self-reported data.

Publications:

Diagnostic circulating biomarkers to detect vision-threatening diabetic retinopathy: Potential screening tool of the future?Karen Frudd, Sobha Sivaprasad, Rajiv Raman, Subramanian Krishnakumar, Yeddula Rebecca Revathy and Patric Turowski.Acta Ophthalmologica Volume100, Issue3 May 2022. https://doi.org/10.1111/aos.14954

Multicenter Evaluation of Diagnostic Circulating Biomarkers to Detect Sight-Threatening Diabetic Retinopathy. Sarega Gurudas, Karen Frudd,  Jayapal Jeya Maheshwari,  Yeddula Rebecca Revathy,  Sobha Sivaprasad,  Shruthi Mahalakshmi Ramanathan,  Vignesh Pooleeswaran, A. Toby Prevost,  Eleni Karatsai,  Sandra Halim, Shruti Chandra, Paul Nderitu,  Dolores Conroy, Subramanian Krishnakumar,  Sowmya Parameswaran,  Kuppamuthu Dharmalingam,  Kim Ramasamy,  Rajiv Raman, Colin Jones, Haralabos Eleftheriadis, John Greenwood and Patric Turowski.  JAMA Ophthalmol. 2022;140(6):587-597.  doi:10.1001/jamaophthalmol.2022.1175